Research News & Breakthroughs
Research moves fast. This page brings you the latest findings in Lyme disease science — explained in plain language, with context for what each development means for patients and the field.
New Biomarker Study Shows Promise for Early Detection
A Yale-led study found that a panel of metabolite biomarkers could identify Lyme infection with 89% sensitivity in the first two weeks of infection — weeks before antibody tests become reliable.
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Neuroinflammation Markers Found in PTLDS Patients
Columbia University researchers published imaging data showing elevated neuroinflammation in a subset of patients with persistent cognitive symptoms after Lyme treatment. The findings support an inflammatory mechanism.
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VLA15 Phase 3 Trial Data Expected This Year
The Pfizer/Valneva Lyme vaccine candidate completed Phase 3 enrollment in late 2023. Final efficacy and safety data are expected to be published in 2026 — potentially paving the way for FDA review.
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Understanding Research Findings
Not all research findings are equally meaningful. Here's how to read them: A single study, particularly a small pilot study, rarely proves anything definitively. Look for replication — findings confirmed by multiple independent research groups carry much more weight. Peer-reviewed journals have an editorial review process that filters out the most significant methodological errors, but are not foolproof. Project Lyme's Scientific Advisory Board reviews all research we communicate to ensure we are representing the evidence accurately and not overstating findings.