Transparency is a core value at Project Lyme. Every dollar donated to research is accounted for here — including what was funded, who received the grant, and what it produced.
Active Grants (2024–2026)
Immune Dysregulation in Post-Treatment Lyme Disease Syndrome
Characterizing immune cell profiles and cytokine signatures in patients with PTLDS to identify therapeutic targets and predictive biomarkers. See Treatment Research for full summary.
Novel Biomarker Detection for Early Lyme Disease
Investigating host-response metabolite and cytokine panels for early detection of Borrelia burgdorferi infection before seroconversion. See Diagnostics Research for full summary.
Gut Microbiome Alterations and Persistent Lyme Symptoms
Investigating whether antibiotic-induced microbiome perturbations correlate with post-treatment symptom persistence and whether probiotic interventions reduce this risk.
Completed Grants (2020–2023)
Direct Pathogen Detection Using Next-Generation Sequencing
Outcome: Proof-of-concept demonstrated that targeted metagenomic sequencing can detect Borrelia DNA in blood samples at concentrations too low for conventional PCR in a small pilot study. Manuscript submitted for peer review.
Neuroinflammation Imaging in Post-Lyme Encephalopathy
Outcome: PET imaging revealed elevated neuroinflammation markers in a subset of patients with cognitive post-treatment symptoms compared to controls. Findings published in PLOS ONE in 2023.
Full Research Reports Available
Annual research impact reports, including detailed outcomes for all funded projects, are available on our Reports page. Downloadable PDFs are also available for donors upon request.